The role of oxidants and antioxidants in varicose veins at tissue level.
Background The role of oxidative stress has not been fully elucidated in the aetiopathogenesis of varicose veins.
Aim The aim of our study was to measure two important parameters of oxidative balance, which may be linked with pathogenesis of varicose veins. The Ferric Reducing Ability of Plasma (FRAP) and Lipid Peroxidation Index (MDA) were measured in withdrawed from a varicose veins and from ulnar vein blood at a time of surgery. The group consisted of 20 males and 60 females with a mean age of a 51-72 years (± 12, SD).
Methods FRAP was measured by Benzie method and malondialdehyde (MDA) using thiobarbituric acid (TBA) method.
Results It was found statistical significance difference between values of FRAP in blood of varicose veins and ulnar venous blood by Mann-Whitney U test (p≤0,05). Values of FRAP were significantly higher in venous blood in comparison of blood from varicose veins.
The study revealed that MDA in blood of varicose veins were significantly higher in comparison to venous blood of the same subjects by Mann-Whitney U test (p≤0,001), which may be linked to the oxidative system of the organism.
Obtained results demonstrate the presence of difference in the oxidant/antioxidant balance between blood of varicose veins compared to ulnar venous blood of the same patients.
Key words antioxidant system, oxidative balance, varicose veins.